Protein binding to the low density lipoprotein receptor promoter in vivo is differentially affected by gene activation in primary human cells.

Protein-DNA interactions within a region of the LDL receptor promoter involved in sterol-mediated feedback repression of transcription were examined using in vivo genomic footprinting with dimethylsulfate (DMS).A broad region of protein-DNA contacts spanning from repeat 1 to beyond the transcription start sites was observed in primary cultures of h

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Ppargamma2 is a key driver of longevity in the mouse.

Aging involves a progressive physiological remodeling that is controlled by both genetic and environmental factors.Many of these factors impact also on white adipose tissue (WAT), which has been shown to be a determinant of lifespan.Interrogating a transcriptional network for predicted causal regulatory interactions in a collection of mouse WAT fro

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